| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Phorbol-12-myristate-13-acetate-induced protein 1;PMA-induced protein 1;Immediate-early-response protein APR;Protein Noxa;PMAIP1;NOXA; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | A synthesized peptide derived from human Noxa |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-Noxa Rabbit Monoclonal Antibody is an antibody targeting PMAIP1. Common applications include WB. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: AAFB-16; isotype: Rabbit IgG; reactivity: Human,Mouse,Rat; observed MW: 16 kDa; calculated MW: 6030 MW.
Boster Bio Anti-Noxa Rabbit Monoclonal Antibody catalog # M02287. Tested in WB application. This antibody reacts with Human, Mouse, Rat.
Key elements and design rationale
- Target: PMAIP1 — Phorbol-12-myristate-13-acetate-induced protein 1
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: AAFB-16; Isotype: Rabbit IgG
- Species reactivity: Human,Mouse,Rat
- Molecular weight guidance: Observed: 16 kDa; Calculated: 6030 MW
Biological background
Protein function (datasheet): Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. .
Cellular localization (datasheet): Mitochondrion .
Tissue details (datasheet): Highly expressed in adult T-cell leukemia cell line.
Research relevance and current trends
- Commonly studied in contexts related to Angiogenesis,Cancer,Cytokines,Immunology,Innate Immunity,Invasion/Microenvironment.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
