| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Protein numb homolog;h-Numb;Protein S171;NUMB; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human NUMB |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-NUMB Rabbit Monoclonal Antibody is an antibody targeting NUMB. Common applications include WB. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: AOGI-14; isotype: Rabbit IgG; reactivity: Human,Mouse,Rat; observed MW: 17 kDa; calculated MW: 70804 MW.
Boster Bio Anti-NUMB Rabbit Monoclonal Antibody catalog # M01206. Tested in WB application. This antibody reacts with Human, Mouse, Rat.
Key elements and design rationale
- Target: NUMB — Protein numb homolog
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: AOGI-14; Isotype: Rabbit IgG
- Species reactivity: Human,Mouse,Rat
- Molecular weight guidance: Observed: 17 kDa; Calculated: 70804 MW
Biological background
Protein function (datasheet): Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
Cellular localization (datasheet): Membrane; Peripheral membrane protein.
Tissue details (datasheet): Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells. .
Research relevance and current trends
- Commonly studied in contexts related to Cytoplasmic,Neurogenesis,Neurology Process,Neuroscience,Signaling Pathways,Stem Cells.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
