| Field | Specification |
|---|---|
| Target | |
| Alternative names | Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Osteoprotegerin |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 27T13 is a rabbit monoclonal antibody that recognizes tumor necrosis factor receptor superfamily member 11B (gene TNFRSF11B) in human samples and is validated for IHC and ICC/IF. The predicted molecular weight is 46.0 kDa.
Osteoprotegerin (OPG, TNFRSF11B) is a secreted decoy receptor that binds RANKL and blocks its interaction with RANK. This prevents osteoclast formation and activation, so the local RANKL/OPG ratio is a key determinant of bone mass. OPG can also bind TRAIL and is studied in bone metabolism, vascular calcification and cancer.
| Target | Tumor necrosis factor receptor superfamily member 11B (gene TNFRSF11B; UniProt O00300, human) |
|---|---|
| Clone | 27T13 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 46.0 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Immunohistochemistry | 1:50–1:200 |
|---|---|
| Immunocytochemistry / Immunofluorescence | 1:50–1:200 |
Immunogen
Synthetic peptide based on the sequence of human osteoprotegerin.
Reactivity Notes
The supplier lists reactivity with human. UniProt describes tumor necrosis factor receptor superfamily member 11B as a secreted protein. Tissue expression noted by UniProt (human): Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Aiqin Shan et al. (2013) Expression of Both Matrix Metalloproteinase-2 and Its Tissue Inhibitor-2 in Tunica Media of Radial Artery in Uremic Patients. Renal Failure. 10.3109/0886022X.2012.741645
