| Field | Specification |
|---|---|
| Target | |
| Alternative names | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha;PGC-1-alpha;PPAR-gamma coactivator 1-alpha;PPARGC-1-alpha;Ligand effect modulator 6;PPARGC1A;LEM6, PGC1, PGC1A, PPARGC1; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human PGC1 alpha |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AOBC-16 is a rabbit monoclonal antibody that recognizes peroxisome proliferator-activated receptor gamma coactivator 1-alpha (gene PPARGC1A) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 91.0 kDa, and the supplier reports an observed band at about 113 kDa.
PGC-1α (PPARGC1A) is a transcriptional coactivator that boosts the activity of nuclear receptors and other transcription factors. It drives mitochondrial biogenesis, oxidative metabolism and adaptive thermogenesis in brown fat, and it regulates gluconeogenesis in liver. PGC-1α is a central target in studies of exercise, energy metabolism and neurodegeneration.
| Target | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (gene PPARGC1A; UniProt Q9UBK2, human) |
|---|---|
| Clone | AOBC-16 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 91.0 kDa |
| Observed MW | 113 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Conditions in the example images (WB): 5–20% gradient SDS-PAGE under reducing conditions, 30 µg lysate per lane, transfer to nitrocellulose membrane, blocking in 5% non-fat milk, primary antibody at 1:500 overnight at 4 °C, HRP-conjugated secondary antibody at 1:5000, ECL detection.
Immunogen
Synthetic peptide based on the sequence of human PGC1 alpha.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. Tissue expression noted by UniProt (human): Heart, skeletal muscle, liver and kidney.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Nan Zhang et al. (2026) Folic acid mitigation of alcohol-induced sarcopenia via gut-muscle axis modulation. Metabolism-Clinical and Experimental. 10.1016/j.metabol.2026.156567
Huifang Zhang et al. (2026) The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)3 exposure in HT22 hippocampal neuronal cells. Free Radical Biology and Medicine. 10.1016/j.freeradbiomed.2026.06.011
Lu Wang et al. (2022) Activation of PGC-1α via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease. Phytotherapy Research. 10.1002/ptr.7334
Bingna Cai et al. (2023) Anti-fatigue effects and mechanism of Syngnathus schlegeli peptides supplementation on exercise-fatigued mice. Journal of Functional Foods. 10.1016/j.jff.2023.105846
Lu Wang et al. (2021) Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury. Phytomedicine. 10.1016/j.phymed.2021.153845
Jincheng Yu et al. (2022) Microencapsulated hawthorn berry polyphenols alleviate exercise fatigue in mice by regulating AMPK signaling pathway and balancing intestinal microflora. Journal of Functional Foods. 10.1016/j.jff.2022.105255
Meng-Ling Ma et al. (2025) Cistanoside F Ameliorates Lipid Accumulation and Enhances Myogenic Differentiation via AMPK-Dependent Signaling in C2C12 Myotubes. Cells. 10.3390/cells14120874
In-Seon Bae et al. (2023) Rabbit Meat Extract Induces Browning in 3T3−L1 Adipocytes via the AMP−Activated Protein Kinase Pathway. Foods. 10.3390/foods12193671
Yu-Kai Cui et al. (2022) Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway. European Journal of Pharmacology. 10.1016/j.ejphar.2022.174858
Xuemei Liao et al. (2010) Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor γ co-activator-1α protein. British Journal of Pharmacology. 10.1111/j.1476-5381.2010.00900.x
