| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP;SNCA;NACP, PARK1; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | A synthesized peptide derived from human Phospho-alpha Synuclein (S129) |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Target | |
| UniProt # |
Overview
Anti-Phospho-alpha Synuclein (S129) SNCA Rabbit Monoclonal Antibody is an antibody targeting SNCA. Common applications include WB, IHC, ICC, IF. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: BBF-19; isotype: Rabbit IgG; reactivity: Human; observed MW: 14 kDa; calculated MW: 14460 MW.
Boster Bio Anti-Phospho-alpha Synuclein (S129) SNCA Rabbit Monoclonal Antibody catalog # P00215-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.
Key elements and design rationale
- Target: SNCA — Alpha-synuclein
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: BBF-19; Isotype: Rabbit IgG
- Species reactivity: Human
- Molecular weight guidance: Observed: 14 kDa; Calculated: 14460 MW
- Phospho site(s): S129
Biological background
Protein function (datasheet): May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Cellular localization (datasheet): Cytoplasm, cytosol . Membrane . Nucleus . Cell junction, synapse . Secreted . Membrane-bound in dopaminergic neurons. .
Tissue details (datasheet): Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Research relevance and current trends
- Commonly studied in contexts related to Alzheimer's Disease,Neurodegenerative Disease,Neurology Process,Neuroscience.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
- Immunofluorescence / ICC: Visualize subcellular localization and co-localization patterns; consider fixation/permeabilization compatibility and controls.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
