| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Signal transducer and activator of transcription 3;Acute-phase response factor;STAT3;APRF; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human Phospho-ErbB2 (Y1139) |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Target | |
| UniProt # |
Boster Bio Anti-Phospho-ErbB2 (Y1139) Rabbit Monoclonal Antibody catalog # P00010-1. Tested in WB, IP applications. This antibody reacts with Human.
Gene: Signal transducer and activator of transcription 3 | Target: ERBB2 | Function: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). . | Research areas: Cancer,Cardiogenesis,Cardiovascular,Developmental Biology,Embryogenesis,Embryonic Stem Cells,Epigenetics and Nuclear Signaling,Hypertrophy,Intracellular,Nuclear Signaling,Nuclear Signaling Pathways,Signal Transduction,Signaling Pathway,Stem Cells,Surface Molecules,Transcription,Transcription Factors,Transcription Factors/Regulators
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 27E43 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human Phospho-ErbB2 (Y1139) | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IP
Observed MW: 185 kDa | Calculated MW: 88068 MW
Cellular localization: Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Tissue details: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Phospho site(s): Y1139
Status: Active
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