Anti-Phospho-Rad17 (S656) Rabbit Monoclonal Antibody

Boster Bio Anti-Phospho-Rad17 (S656) Rabbit Monoclonal Antibody catalog # P02159-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Gene: Replication protein A 32 kDa subunit | Target: RAD17 | Function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. . | Research areas: DNA/RNA,DNA Damage & Repair,DNA Damage Response,DNA Synthesis,Epigenetics and Nuclear Signaling

Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 28R30 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human Phospho-Rad17 (S656) | Concentration: 0.5mg/ml | Purification: Affinity-chromatography

Applications: WB, IHC, IF, ICC

Observed MW: 85 kDa | Calculated MW: 29247 MW

Cellular localization: Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .

Tissue details: Expressed in brain, and to a lesser extent in lung, kidney and testis.

Phospho site(s): S656

Status: Active

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