| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Tissue-type plasminogen activator;t-PA;t-plasminogen activator;tPA;3.4.21.68;Alteplase;Reteplase;Tissue-type plasminogen activator chain A;Tissue-type plasminogen activator chain B;PLAT; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human PLAT |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-PLAT/Tpa Rabbit Monoclonal Antibody is an antibody targeting PLAT. Common applications include WB, IHC. Key specifications include host: Rabbit; clonality: Monoclonal; clone: Clone: AOAC-16; isotype: Rabbit IgG; reactivity: Human,Mouse,Rat; observed MW: 28 kDa; calculated MW: 62917 MW.
Boster Bio Anti-PLAT/Tpa Rabbit Monoclonal Antibody catalog # M02965. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Key elements and design rationale
- Target: PLAT — Tissue-type plasminogen activator
- Antibody format: Host: Rabbit; Clonality: Monoclonal; Clone: Clone: AOAC-16; Isotype: Rabbit IgG
- Species reactivity: Human,Mouse,Rat
- Molecular weight guidance: Observed: 28 kDa; Calculated: 62917 MW
Biological background
Protein function (datasheet): Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a role in facilitating neuronal migration.
Cellular localization (datasheet): Secreted, extracellular space.
Tissue details (datasheet): Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Research relevance and current trends
- Commonly studied in contexts related to Cancer,Cell Biology,Drug Metabolism,Energy Metabolism,Energy Transfer Pathways,Metabolic Signaling Pathways,Metabolism,Mitochondrial,Mitochondrial Markers,Mitochondrial Metabolism,Neuroscience,Neurotransmitter,Oxidative Stress,Pathways and Processes,Redox Metabolism,Signal Transduction.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
