| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Mitogen-activated protein kinase 7;MAP kinase 7;MAPK 7;2.7.11.24;Big MAP kinase 1;BMK-1;Extracellular signal-regulated kinase 5;ERK-5;MAPK7;BMK1, ERK5, PRKM7; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | A synthesized peptide derived from human PNMT |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-PNMT Rabbit Monoclonal Antibody catalog # M02813-2. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Mitogen-activated protein kinase 7 | Target: PNMT | Function: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. . | Research areas: Intracellular Signaling,Kinases,MAPK Pathway,Neural Signal Transduction,Neurology Process,Neuroscience,Neurotransmission,Protein Phosphorylation,Ser/Thr Kinases,Signal Transduction
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 28P11 | Isotype: IgG | Reactivity: Human,Mouse | Immunogen: A synthesized peptide derived from human PNMT | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IF, ICC
Observed MW: 31 kDa | Calculated MW: 88386 MW
Cellular localization: Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.
Tissue details: Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver. .
Status: Active
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