| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Drebrin;Developmentally-regulated brain protein;DBN1;D0S117E; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human PPCS |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-PPCS Rabbit Monoclonal Antibody catalog # M05567-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Drebrin | Target: PPCS | Function: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. . | Research areas: Signal Transduction,Cytoskeleton,Cytoskeleton/ECM,Actin Assembly,Actin, etc.,Microfilaments
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 29P15 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human PPCS | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IHC, IF, ICC
Observed MW: 34 kDa | Calculated MW: 71429 MW
Cellular localization: Cytoplasm . Cytoplasm, cell cortex . Cell junction . Cell projection . Cell projection, growth cone . In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). .
Tissue details: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level). .
Status: Active
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