| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Chondroitin sulfate proteoglycan 4;Chondroitin sulfate proteoglycan NG2;Melanoma chondroitin sulfate proteoglycan;Melanoma-associated chondroitin sulfate proteoglycan;CSPG4;MCSP; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human PRD |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-PRD Rabbit Monoclonal Antibody catalog # M03417-2. Tested in WB application. This antibody reacts with Human.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Chondroitin sulfate proteoglycan 4 | Target: PEPD | Function: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2 (VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N- terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin- mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. . | Research areas: Apoptosis,Associated Proteins,Calcium Binding Proteins,Calcium Signaling,Cancer,Cell Biology,Cell Death,Cytoskeleton,Cytoskeleton/ECM,Microtubules,Receptors,Signal Transduction,Signaling Pathway
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 30P28 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human PRD | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB
Observed MW: 55 kDa | Calculated MW: 250537 MW
Cellular localization: Cell membrane ; Single-pass type I membrane protein ; Extracellular side . Apical cell membrane ; Single-pass type I membrane protein ; Extracellular side . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein ; Extracellular side . Cell surface . Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes (By similarity). .
Tissue details: Detected only in malignant melanoma cells. .
Status: Active
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