| Field | Specification |
|---|---|
| Target | |
| Alternative names | Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; PROC |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human Protein C |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17P73 is a rabbit monoclonal antibody that recognizes vitamin K-dependent protein C (gene PROC) in human samples and is validated for Western blot. The predicted molecular weight is 52.1 kDa, and the supplier reports an observed band at about 52 kDa.
Protein C (PROC) is a vitamin K-dependent plasma zymogen made in the liver. After activation by the thrombin-thrombomodulin complex, activated protein C cleaves and inactivates coagulation factors Va and VIIIa with protein S as cofactor, providing a major natural anticoagulant brake, and it also has cytoprotective effects on endothelium.
| Target | Vitamin K-dependent protein C (gene PROC; UniProt P04070, human) |
|---|---|
| Clone | 17P73 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 52.1 kDa |
| Observed MW | 52 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Samples with a confirmed band (WB): HepG2 cells.
Recommended loading (WB): 20–40 µg of total protein per lane.
Immunogen
Synthetic peptide based on the sequence of human protein C.
Reactivity Notes
The supplier lists reactivity with human. UniProt describes vitamin K-dependent protein C as secreted and also located in the Golgi apparatus and endoplasmic reticulum. Tissue expression noted by UniProt (human): Plasma. The samples tested by the supplier (listed above) are a practical starting point for positive controls.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
