| Field | Specification |
|---|---|
| Target | |
| Alternative names | Retinoschisin; X-linked juvenile retinoschisis protein; RS1; XLRS1 |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human RS1 recombinant protein (Position: Y34-A224). Human RS1 shares 96.9% amino acid (aa) sequence identity with mouse RS1. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes retinoschisin (gene RS1) in human and mouse samples and is validated for Western blot and ELISA.
Retinoschisin (RS1) is a secreted discoidin-domain protein made by photoreceptors and bipolar cells that forms octamers binding the surface of retinal cells. It helps maintain the layered architecture and cell adhesion of the retina, and mutations in RS1 cause X-linked retinoschisis.
| Target | Retinoschisin (gene RS1; UniProt O15537, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human, Mouse |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Mouse) |
|---|---|
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human RS1 fragment (Tyr34–Ala224), expressed in E. coli. Sequence identity with the mouse ortholog: 96.9%.
Reactivity Notes
The supplier lists reactivity with human and mouse. UniProt describes retinoschisin as secreted and also located in the cell membrane. Tissue expression noted by UniProt (human): Restricted to the retina (at protein level).
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
