| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | E3 ubiquitin-protein ligase BRE1A;BRE1-A;hBRE1;6.3.2.-;RING finger protein 20;RNF20;BRE1A; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human SAFB |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-SAFB Rabbit Monoclonal Antibody catalog # M03458-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: E3 ubiquitin-protein ligase BRE1A | Target: SAFB | Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. . | Research areas: Cell Biology,Chromatin Modifying Enzymes,Epigenetics and Nuclear Signaling,Histones,Proteasome / Ubiquitin,Proteolysis/Ubiquitin,Ring Finger E3 Ligase,Ubiquitin E3 Enzymes
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 30S09 | Isotype: IgG | Reactivity: Human,Mouse,Rat | Immunogen: A synthesized peptide derived from human SAFB | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IHC, IF, ICC
Observed MW: 150 kDa | Calculated MW: 113662 MW
Cellular localization: Nucleus .
Tissue details: Expressed in the normal brain and also in malignant gliomas (at protein level). .
Status: Active
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