| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | NAD-dependent protein deacylase sirtuin-5, mitochondrial ;3.5.1.- ;Regulatory protein SIR2 homolog 5 ;SIR2-like protein 5 ;SIRT5 ;SIR2L5; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human SBDS |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-SBDS Rabbit Monoclonal Antibody catalog # M02396. Tested in WB application. This antibody reacts with Human, Mouse, Rat.
Protein: Lysosome-associated membrane glycoprotein 2 (Lamp2) | Gene: NAD-dependent protein deacylase sirtuin-5, mitochondrial | Target: SBDS | Function: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. . | Research areas: Acetylation,Cancer,Cardiovascular,Chromatin Modifying Enzymes,Epigenetics and Nuclear Signaling,Metabolism
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 26S97 | Isotype: IgG | Reactivity: Human,Mouse,Rat | Immunogen: A synthesized peptide derived from human SBDS | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB
Observed MW: 29 kDa | Calculated MW: 33881 MW
Cellular localization: Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.
Tissue details: Widely expressed. .
Status: Active
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