| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | 5'-AMP-activated protein kinase subunit gamma-1;AMPK gamma1;AMPK subunit gamma-1;AMPKg;PRKAG1; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human SLC12A1 / NKCC2 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-SLC12A1 / NKCC2 Rabbit Monoclonal Antibody catalog # M04473. Tested in WB application. This antibody reacts with Human.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: 5'-AMP-activated protein kinase subunit gamma-1 | Target: SLC12A1 | Function: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by inly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. . | Research areas: Cell Adhesion,Cell Type Markers,Cytoskeleton/ECM,Hematopoietic Progenitors,Immunology,Integrins,Myeloid,Signal Transduction,Stem Cells
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 29S41 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human SLC12A1 / NKCC2 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB
Observed MW: 150 kDa | Calculated MW: 37579 MW
Cellular localization: Membrane; Single-pass type I membrane protein.
Tissue details: Leukocytes.
Status: Active
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