| Field | Specification |
|---|---|
| Target | |
| Alternative names | Serine protease inhibitor Kazal-type 5; Lympho-epithelial Kazal-type-related inhibitor; LEKTI; SPINK5 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human SPINK5 / LEKTI |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 29S14 is a rabbit monoclonal antibody that recognizes serine protease inhibitor Kazal-type 5 (gene SPINK5) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 120.7 kDa, and the supplier reports an observed band at about 121 kDa.
Serine protease inhibitor Kazal-type 5 (SPINK5, also called LEKTI) is a multidomain protease inhibitor expressed in skin and mucosal epithelia. It controls kallikreins such as KLK5 and KLK7 that drive shedding of the outer skin layer, and loss-of-function mutations cause Netherton syndrome, a severe skin barrier disorder.
| Target | Serine protease inhibitor Kazal-type 5 (gene SPINK5; UniProt Q9NQ38, human) |
|---|---|
| Clone | 29S14 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 120.7 kDa |
| Observed MW | 121 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human SPINK5 / LEKTI.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt describes serine protease inhibitor Kazal-type 5 as a secreted protein. Tissue expression noted by UniProt (human): Highly expressed in the thymus and stratum corneum.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
