| Field | Specification |
|---|---|
| Target | |
| Alternative names | Transforming growth factor beta-1 proprotein; TGFB1; TGFB |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human TGF beta 1 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17T29 is a rabbit monoclonal antibody that recognizes transforming growth factor beta-1 proprotein (gene TGFB1) in human samples and is validated for Western blot. The predicted molecular weight is 44.3 kDa, and the supplier reports an observed band at about 48 kDa.
TGF-β1 is the prototypical member of the TGF-β family of cytokines. It is secreted in a latent form held by its latency-associated peptide and, once activated, signals through TGFBR1/TGFBR2 and SMAD proteins to control cell growth, differentiation, extracellular matrix production and immune tolerance, making it central to fibrosis, immunology and cancer research.
| Target | Transforming growth factor beta-1 proprotein (gene TGFB1; UniProt P01137, human) |
|---|---|
| Clone | 17T29 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 44.3 kDa |
| Observed MW | 48 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human TGF beta 1.
Reactivity Notes
The supplier lists reactivity with human. Tissue expression noted by UniProt (human): Highly expressed in bone.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Kaiqiang Meng et al. (2025) The mutualistic relationship between M2c macrophages of TGFβ1 induction and gastric cancer cells: the correlation between protective mechanisms in the tumor microenvironment and polarization of subtypes of cells. Journal of Cancer. 10.7150/jca.97784
Run Xu et al. (2021) MicroRNA‑181a promotes epithelial‑mesenchymal transition in esophageal squamous cell carcinoma via the TGF‑β/Smad pathway. Molecular Medicine Reports. 10.3892/mmr.2021.11955
Yu Li et al. (2013) The Anti-Lung Cancer Activities of Steroidal Saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through Enhanced Immunostimulation in Experimental Lewis Tumor-Bearing C57BL/6 Mice and Induction of Apoptosis in the A549 Cell Line. Molecules. 10.3390/molecules181012916
Shi‑Qi Zhao et al. (2017) HMGB1, TGF‑β and NF‑κB are associated with chronic allograft nephropathy. Experimental and Therapeutic Medicine. 10.3892/etm.2017.5319
Jiang Yong-Liang et al. (2006) Transforming Growth Factor-β1 Induces Transdifferentiation of Fibroblasts into Myofibroblasts in Hypoxic Pulmonary Vascular Remodeling. ACTA Biochimica et Biophysica Sinica. 10.1111/j.1745-7270.2006.00123.x
Wang Wen et al. (2019) Berberine Attenuates Cigarette Smoke Extract-induced Airway Inflammation in Mice: Involvement of TGF-β1/Smads Signaling Pathway. Current Medical Science. 10.1007/s11596-019-2101-8
