| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Caspase-10;CASP-10;3.4.22.63;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4;Caspase-10 subunit p23/17;Caspase-10 subunit p12;CASP10;MCH4; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | A synthesized peptide derived from human TMF |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-TMF Rabbit Monoclonal Antibody catalog # M02214. Tested in WB, ICC/IF applications. This antibody reacts with Human.
Protein: Lysosome-associated membrane glycoprotein 2 (Lamp2) | Gene: Caspase-10 | Target: TMF1 | Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. . | Research areas: Adaptive Immunity,Alzheimer's Disease,Cancer,Cell Biology,Cell Cycle,Cell Division,Chromatin Remodeling,Chromosome Structure,Epigenetics and Nuclear Signaling,ER Proteins,Immunology,Neurodegenerative Disease,Neurology Process,Neuroscience,Oncoproteins,Oncoproteins/Suppressors,Protein Phosphorylation,Protein Trafficking,Ser/Thr Phosphatases,Signal Transduction,T Cells
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 30T88 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human TMF | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IF, ICC
Observed MW: 160 kDa | Calculated MW: 58951 MW
Cellular localization: Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .
Tissue details: Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Status: Active
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