| Field | Specification |
|---|---|
| Target | |
| Alternative names | Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; LTA; TNFB; TNFSF1 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human TNF beta |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 17L36 is a rabbit monoclonal antibody that recognizes lymphotoxin-alpha (gene LTA) in human samples and is validated for Western blot. The predicted molecular weight is 22.3 kDa, and the supplier reports an observed band at about 18 kDa.
Lymphotoxin-alpha (LTA, also called TNF-β) is a TNF-family cytokine made mainly by activated lymphocytes. As a soluble homotrimer it signals through TNFR1, TNFR2 and HVEM, and as a membrane complex with lymphotoxin-beta it engages the lymphotoxin-beta receptor, which is essential for lymph node and other lymphoid organ development; it is studied in inflammation and lymphoid tissue organization.
| Target | Lymphotoxin-alpha (gene LTA; UniProt P01374, human) |
|---|---|
| Clone | 17L36 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 22.3 kDa |
| Observed MW | 18 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human TNF beta.
Reactivity Notes
The supplier lists reactivity with human. UniProt describes lymphotoxin-alpha as secreted and also located in the membrane.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
Jimeng Zhao et al. (2022) Effects of Herb-Partitioned Moxibustion on Autophagy and Immune Activity in the Colon Tissue of Rats with Crohn’s Disease. Evidence-based Complementary and Alternative Medicine. 10.1155/2022/3534874
