Anti-TNFRSF14 Antibody Picoband®

Overview

This antibody is intended for detection of TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.

Vendor notes: Boster Bio Anti-TNFRSF14 Antibody Picoband® catalog # PB10104. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Key elements and design rationale

• Antibody format: Rabbit Polyclonal Rabbit IgG
• Immunogen / epitope context: E. coli-derived human TNFRSF14/HVEM recombinant protein (Position: L39-V202). (reported region: L39-V202).
• Molecular weight context: reported MW: 37 kDa; calculated MW: 30392 MW
• Reactivity: Human
• Applications: ELISA, WB

As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.

Biological background

Tumor necrosis factor receptor superfamily member 14; Tumor necrosis factor receptor superfamily member 14. Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. Functional note: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells. . Reported localization: Membrane ; Single-pass type I membrane protein . Expression/tissue context: Widely expressed, with the highest expression in lung, spleen and thymus.

Research relevance and current trends

• Antiviral Signaling: Researchers commonly examine how TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) relates to this theme using model systems and orthogonal readouts.
• Cancer: Researchers commonly examine how TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) relates to this theme using model systems and orthogonal readouts.
• Cytokines: Researchers commonly examine how TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) relates to this theme using model systems and orthogonal readouts.

Common research applications

• Western blotting: compare relative TNFRSF14 (Tumor necrosis factor receptor superfamily member 14) levels across conditions; band patterns may reflect isoforms and processing.
• ELISA-compatible use: when applicable, interpret signal as relative abundance across sample sets with consistent handling and dilution strategy.

Notes for experimental interpretation

• Specificity notes: No cross reactivity with other proteins.
• Cross-reactivity: No cross-reactivity with other proteins.
• Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
• Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.