| Field | Specification |
|---|---|
| Target | |
| Alternative names | Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD antigen CD110; MPL; TPOR |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human TPOR |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone 18M14 is a rabbit monoclonal antibody that recognizes thrombopoietin receptor (gene MPL) in human, mouse and rat samples and is validated for Western blot. The predicted molecular weight is 71.2 kDa, and the supplier reports an observed band at about 82 kDa.
The thrombopoietin receptor (MPL, CD110) is a cytokine receptor on hematopoietic stem cells and megakaryocytes. When thrombopoietin binds, MPL activates JAK2 and STAT5 signaling to drive stem cell maintenance, megakaryocyte growth and platelet production, and activating MPL mutations are found in some myeloproliferative neoplasms.
| Target | Thrombopoietin receptor (gene MPL; UniProt P40238, human) |
|---|---|
| Clone | 18M14 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 71.2 kDa |
| Observed MW | 82 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|
Immunogen
Synthetic peptide based on the sequence of human TPOR.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places thrombopoietin receptor in the cell membrane, Golgi apparatus and cell surface. Tissue expression noted by UniProt (human): Expressed at a low level in a large number of cells of hematopoietic origin.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
