| Field | Specification |
|---|---|
| Target | |
| Alternative names | Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2; Telomeric DNA-binding protein; TERF2; TRBF2; TRF2 |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human TRF2. |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone AFOB-20 is a rabbit monoclonal antibody that recognizes telomeric repeat-binding factor 2 (gene TERF2) in human samples and is validated for Western blot, IHC and ICC/IF. The predicted molecular weight is 59.6 kDa, and the supplier reports an observed band at about 66 kDa.
TRF2 (TERF2) is a shelterin subunit that binds double-stranded telomeric TTAGGG repeats and is essential for protecting chromosome ends. It prevents telomeres from being recognized as DNA breaks, blocking ATM activation and end-to-end fusions, and it recruits factors such as RAP1 and Apollo.
| Target | Telomeric repeat-binding factor 2 (gene TERF2; UniProt Q15554, human) |
|---|---|
| Clone | AFOB-20 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 59.6 kDa |
| Observed MW | 66 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence | 1:50–1:200 |
Immunogen
Synthetic peptide based on the sequence of human TRF2.
Reactivity Notes
The supplier lists reactivity with human. UniProt places telomeric repeat-binding factor 2 in the nucleus and chromosome. Tissue expression noted by UniProt (human): Ubiquitous.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
