| Field | Specification |
|---|---|
| Target | |
| Alternative names | Transient receptor potential cation channel subfamily V member 4; TrpV4; Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL2; VROAC |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | E.coli-derived human TRPV4 recombinant protein (Position: R64-D408). Human TRPV4 shares 97.4% amino acid (aa) sequence identity with both mouse and rat TRPV4. |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Lyophilized |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody recognizes transient receptor potential cation channel subfamily V member 4 (gene TRPV4) in human, mouse and rat samples and is validated for Western blot and ELISA.
TRPV4 is a calcium-permeable cation channel that senses osmotic and mechanical changes, as well as warmth and certain chemical activators. It is expressed in many tissues, including endothelium, kidney, skin and cartilage, where it supports barrier formation and cell volume and pressure sensing. Variants in TRPV4 are well known in inherited skeletal dysplasias and neuropathies.
| Target | Transient receptor potential cation channel subfamily V member 4 (gene TRPV4; UniProt Q9HBA0, human) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / IgG |
| Reactivity | Human, Mouse, Rat |
| Purification | Immunogen affinity purified |
| Form | Lyophilized |
| Formulation | Per vial: 4 mg trehalose; 0.9 mg NaCl; 0.2 mg Na2HPO4 |
| Reconstitution | 500 µg/mL after adding 0.2 mL distilled water |
| Storage | As supplied: −20 °C for up to 12 months from receipt. After reconstitution: 4 °C for up to 1 month, or aliquot and keep at −20 °C for up to 6 months. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 0.25–0.5 µg/mL (Mouse, Rat) |
|---|---|
| ELISA | 0.1–0.5 µg/mL |
Immunogen
Recombinant human TRPV4 fragment (Arg64–Asp408), expressed in E. coli. Sequence identity with the mouse and rat orthologs: 97.4%.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places transient receptor potential cation channel subfamily V member 4 in the cell membrane, apical cell membrane, cell junction and cell projection. Tissue expression noted by UniProt (human): Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
