| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform ;MLC-2 ;MLC-2v;Cardiac myosin light chain 2 ;Myosin light chain 2, slow skeletal/ventricular muscle isoform ;MLC-2s/v ;Ventricular myosin light chain 2 ;MYL2 ;MLC2 ; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human TRPV5 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-TRPV5 Rabbit Monoclonal Antibody catalog # M03218. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | Target: TRPV5 | Function: Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). . | Research areas: Motor Proteins,Myosin,Signal Transduction
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 27T91 | Isotype: IgG | Reactivity: Human,Mouse,Rat | Immunogen: A synthesized peptide derived from human TRPV5 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IHC
Observed MW: 100 kDa | Calculated MW: 18789 MW
Cellular localization: Cytoplasm, myofibril, sarcomere, A band .
Tissue details: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. .
Status: Active
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