| Field | Specification |
|---|---|
| Target | |
| Alternative names | ALK tyrosine kinase receptor; Anaplastic lymphoma kinase 2; alk-2; Anaplastic lymphoma kinase homolog; alk |
| Gene ID | |
| UniProt # | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Conjugate | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
This rabbit polyclonal antibody targets ALK tyrosine kinase receptor in zebrafish samples and is validated for IHC.
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase expressed mainly in the developing nervous system. Chromosomal rearrangements that create ALK fusion proteins, such as NPM-ALK and EML4-ALK, and activating ALK mutations drive anaplastic large cell lymphoma, lung cancer and neuroblastoma, making ALK an important cancer research and drug target.
| Target | ALK tyrosine kinase receptor (gene alk; UniProt F8W3R9, zebrafish) |
|---|---|
| Host / Clonality / Isotype | Rabbit / Polyclonal / Rabbit IgG |
| Reactivity | Zebrafish |
| Form | Liquid |
| Formulation | 20 mM PBS; 50% glycerol; 0.02% NaN3 |
| Storage | Store at −20 °C for up to 12 months or 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| IHC (paraffin sections) | 2–5 µg/mL |
|---|
Samples with confirmed staining (IHC): zebrafish brain tissue.
Recommended antigen retrieval: heat-mediated, in TE buffer (pH 9.0); citrate buffer (pH 6.0) can be used instead.
Conditions in the example images (IHC): heat-mediated antigen retrieval in EDTA buffer (pH 8.0).
Reactivity Notes
The supplier lists reactivity with zebrafish. UniProt places ALK tyrosine kinase receptor in the cell membrane. Tissue expression noted by UniProt (zebrafish): Highly expressed in the developing central nervous system: highly expressed in brain, with much lower expression in heart, caudal fin and testis.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
