| Field | Specification |
|---|---|
| Target | |
| Alternative names | E3 ubiquitin-protein ligase ZNRF2;6.3.2.-;Protein Ells2;RING finger protein 202;Zinc/RING finger protein 2;ZNRF2;RNF202; |
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | A synthesized peptide derived from human ZNRF2 |
| Molecular weight | |
| Purification | |
| Reconstitution | |
| Cellular localization | |
| Concentration | |
| Form | Liquid |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
Clone IGB-26 is a rabbit monoclonal antibody that recognizes E3 ubiquitin-protein ligase ZNRF2 in human, mouse and rat samples and is validated for Western blot and IHC. The predicted molecular weight is 24.1 kDa, and the supplier reports an observed band at about 24 kDa.
ZNRF2 is a membrane-associated RING-finger E3 ubiquitin ligase found in neurons and other cells. It ubiquitinates the Na+/K+-ATPase α1 subunit and has been linked to lysosomal regulation of mTORC1 signaling, and it is studied in neuronal transmission and nutrient-sensing pathways.
| Target | E3 ubiquitin-protein ligase ZNRF2 (gene ZNRF2; UniProt Q8NHG8, human) |
|---|---|
| Clone | IGB-26 |
| Host / Clonality / Isotype | Rabbit / Monoclonal / Rabbit IgG |
| Reactivity | Human, Mouse, Rat |
| Form | Liquid |
| Formulation | PBS (pH 7.4); 150 mM NaCl; 0.02% sodium azide; 50% glycerol; plus stabilizers |
| Calculated MW | 24.1 kDa |
| Observed MW | 24 kDa |
| Storage | Long term: −20 °C for up to 12 months. Frequent use: 4 °C for up to 1 month. Avoid repeated freeze–thaw cycles. |
Validated Applications
| Western blot | 1:500–1:2000 |
|---|---|
| Immunohistochemistry | 1:50–1:100 |
Immunogen
Synthetic peptide based on the sequence of human ZNRF2.
Reactivity Notes
The supplier lists reactivity with human, mouse and rat. UniProt places E3 ubiquitin-protein ligase ZNRF2 in the endosome membrane, lysosome membrane, presynaptic cell membrane and cytoplasm. Tissue expression noted by UniProt (human): Highly expressed in the brain, with higher expression during development than in adult.
Safety
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
