| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H25FN4O9 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antibacterial agent 128 is a siderophore analog-ciprofloxacin conjugate joined by a cleavable linker. It shows antibiotic activity against P. aeruginosa (MIC 0.25-64 μg/mL) and B. pseudomallei (MIC 1-32 μg/mL)[1]. Its molecular formula is C26H25FN4O9, with a molecular weight of 556.50 g/mol.
Physical & Chemical Properties
| CAS Number | 3059046-75-9 |
|---|---|
| Molecular Formula | C26H25FN4O9 |
| Molecular Weight | 556.50 g/mol |
| SMILES | CC(OC(N1CCN(CC1)C2=CC3=C(C(C(C(O)=O)=CN3C4CC4)=O)C=C2F)=O)OC(C5=CC(C(O)=CN5)=O)=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
MIC: 0.25-64 μg/mL (P. aeruginosa), 1-32 μg/mL (B. pseudomallei), 4-128 μg/mL (B. thailandensis)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antibacterial agent 128 carries a hydroxypyridinone moiety joined through a cleavable linker and is active on a large panel of P. aeruginosa strains (MIC = 0.25-64 μg/mL), B. pseudomallei strains (MIC = 1-32 μg/mL), and B. thailandensis strains (MIC = 4-128 μg/mL). Antibacterial agent 128 is also active on the Ciprofloxacin-resistant strain AM85 of P. aeruginosa, without cytotoxicity[1]. A promising strategy for bypassing the bacteria cell membrane and restoring the activity of conventional antibiotics such as Ciprofloxacin is the use of iron transport systems. The siderophore analogs correspond to a mono-catechol or a hydroxypyridinone moiety, which both Pseudomonas and Burkholderia species recognize. Physico-chemical studies show that the conjugates (i) cannot interact with the membrane and cannot cross it by passive diffusion, and (ii) remain stable in a physiologic environment when a cleavable linker is present[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
