| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H15ClN2O2S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Anticancer agent 122 is an inhibitor of human lactate dehydrogenase A (hLDHA) reported to have good anticancer activity, and it can be applied in anticancer research[1]. It has a molecular formula of C18H15ClN2O2S and a molecular weight of 358.84 g/mol.
Physical & Chemical Properties
| CAS Number | 2924532-50-1 |
|---|---|
| Molecular Formula | C18H15ClN2O2S |
| Molecular Weight | 358.84 g/mol |
| SMILES | O=C(OC)C/N=C1SC=C(C2=CC=CC=C2)N/1C3=CC=C(Cl)C=C3 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Anticancer agent 122 (0-100 μM; 72 hours) inhibits the liver cancer cell line HepG2 and the cervical cancer cell line SiHa, with IC50s of 5.15 μM and 1.65 μM, respectively, while showing no noticeable toxicity in the human embryonic kidney cell line HEK293[1].
Cell Cytotoxicity Assay[1]
| Cell Line | HEK293, HepG2 and SiHa |
|---|---|
| Concentration | 0-100 μM |
| Incubation Time | 72 hours |
| Result | Inhibited liver cancer cell line HepG2 cells and cervical cancer cell line SiHa cells with IC50s of 5.15 μΜ and 1.65 μΜ，respectively. Had not noticeable toxicity in HEK293. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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