| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C50H43Br2N2P |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Anticancer agent 52 is a potent anticancer agent that shows in vitro cytotoxicity and induces apoptosis. It exhibits an antitumor effect and has potential application in bladder cancer research[1]. It has the molecular formula C50H43Br2N2P (MW 862.67).
Physical & Chemical Properties
| CAS Number | 2388983-64-8 |
|---|---|
| Molecular Formula | C50H43Br2N2P |
| Molecular Weight | 862.67 g/mol |
| SMILES | C1([P+](C2=CC=CC=C2)(C3=CC=CC=C3)CCCC4=[N+](C5=C(N4CC6=CC7=C(C=C6)C=CC=C7)C=CC=C5)CC8=CC=C9C=CC=CC9=C8)=CC=CC=C1.[Br-].[Br-] |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Anticancer agent 52 (compound TPP1) (0-2048 μM) is cytotoxic, with IC50 values of 200 μM (5637), 200 μM (RT112), 150 μM (RT4), 200 μM (SWT80), 240 μM (TCCSUP), and 80 μM (UMUC3)[1].
Apoptosis Analysis[1]
| Cell Line | RT112 cells |
|---|---|
| Concentration | 200 μM |
| Incubation Time | 1, 2, 4 h |
| Result | Induced apoptosis with the increased the expression of c-PARP. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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