| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H19BrClFN6O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antifungal agent 84 is an antifungal compound that inhibits candidiasis in a CNB1-dependent way. It also inhibits the viability of C. albicans biofilm[1]. It has the molecular formula C25H19BrClFN6O and a molecular weight of 553.81 g/mol.
Physical & Chemical Properties
| CAS Number | 2901064-07-9 |
|---|---|
| Molecular Formula | C25H19BrClFN6O |
| Molecular Weight | 553.81 g/mol |
| SMILES | ClC(C=CC=C1)=C1C2=NN(N=N2)CCCN3C(CN=C(C4=C3C=CC(F)=C4)C5=C(C=CC=C5)Br)=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antibacterial agent 84 (1-16 μg/mL) inhibits the growth of the human pathogen C. albicans SC5314[1]. Antibacterial agent 84 (16 μg/mL, 18 h) triggers CNB1-dependent production of endogenous reactive oxygen species (ROS) in C. albicans[1]. In C. albicans, Antibacterial agent 84 (16 μg/mL, 18 h) is cytotoxic via lysosomal membrane permeabilization[1]. At 16 μg/mL for 18 h, Antibacterial agent 84 promotes phagocytosis of C. albicans by macrophages[1]. Antibacterial agent 84 (0.06-32 μg/mL) inhibits ergosterol synthesis in cultures of C. albicans and C. tropicalis[1].
Cell Viability Assay[1]
| Cell Line | C. albicans (SC5314) |
|---|---|
| Concentration | 1-16 μg/mL |
| Incubation Time | 18 or 48 h |
| Result | Inhibited C. albicans SC5314 growth by nearly 100%. |
In Vivo
In G. mellonella larvae infected with C. albicans, Antibacterial agent 84 (16 μg/mL, injected into the right pro-leg) helps clear the fungi 1 h after infection[1].
| Animal Model | G. mellonella larvae infected by C. albicans[1] |
|---|---|
| Dosage | 16 μg/mL |
| Administration | Injected into the right pro-leg of the last instar larvae. |
| Result | Realized the clearance of fungi 1 h post-infection. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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