| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C29H26Cl2N4O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antileishmanial agent-22 is a parasite and antibacterial inhibitor with antileishmanial, antimalarial and anti-tubercular activities. It inhibits Leishmania via an antifolate mechanism (IC50 = 0.408 μM), inhibiting folic acid and folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. It also inhibits P. berghei, with 96.67% suppression in vivo at 48.4 μM/kg/day and an IC50 of 0.038 μM in vitro, and inhibits M. tuberculosis with an MIC of 28.44 μM[1]. It has the molecular formula C29H26Cl2N4O3 and a molecular weight of 549.45 g/mol.
Physical & Chemical Properties
| Molecular Formula | C29H26Cl2N4O3 |
|---|---|
| Molecular Weight | 549.45 g/mol |
| SMILES | O=C(C1CCN(C(C)=O)CC1)NCC2=CC=C3CCC4=C(NC(C(C#N)=C4C5=C(Cl)C=CC(Cl)=C5)=O)C3=C2 |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 0.408 μM (leishmanial), 0.038 μM (P. berghei); MIC: 28.44 μM (M. tuberculosis)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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