| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C24H23ClF3N5O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antimalarial agent 23 is an antimalarial benzimidazole, with IC50 values of 0.08 μM against PfNF54 and 0.10 μM against PfK1. It shows potent inhibition of β-hematin, without directly inhibiting the conversion of heme to hemozoin[1]. It has a molecular formula of C24H23ClF3N5O and a molecular weight of 489.92 g/mol.
Physical & Chemical Properties
| Molecular Formula | C24H23ClF3N5O |
|---|---|
| Molecular Weight | 489.92 g/mol |
| SMILES | CCN(CC1=C(C=C(C=C1)Cl)O)CCNC2=NC=C3N=C(NC3=C2)C4=CC=CC(C(F)(F)F)=C4 |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antimalarial agent 23 is cytotoxic to CHO cells, with an IC50 of 37.3 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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