| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C36H56N24 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antimicrobial agent-7 is a potent antimicrobial agent with an MIC range of 2-8 μg/mL against both Gram-negative and Gram-positive bacteria. It also shows anti-inflammatory activity against lipopolysaccharide-induced inflammation[1]. Its molecular formula is C36H56N24, with a molecular weight of 824.99 g/mol.
Physical & Chemical Properties
| Molecular Formula | C36H56N24 |
|---|---|
| Molecular Weight | 824.99 g/mol |
| SMILES | NC(NCCNC1=NC(NCCNC(N)=N)=NC(N(C(CN2C3=NC(NCCNC(N)=N)=NC(NCCNC(N)=N)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1)=N |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antimicrobial agent-7 (2.8-56.4 μM; 24 h) inhibits the growth of Gram-negative and Gram-positive bacteria[1]. In RAW 264.7 cells stimulated with lipopolysaccharide, Antimicrobial agent-7 (5 and 20 μg/mL; 18 h) inhibits production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α)[1]. Antimicrobial agent-7 shows proteolytic resistance and salt/serum stability[1]. Antimicrobial agent-7 has synergistic or additive effects when combined with selected clinically used antibiotics[1].
Cell Viability Assay[1]
| Cell Line | E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621] |
|---|---|
| Concentration | 2.8-56.4 μM |
| Incubation Time | 24 hours |
| Result | Inhibited Gram-negative bacteria with MIC values of 17.7 and 4.8 μM for E. coli [KCTC 1682] and P. aeruginosa [KCTC 1637], respectively. Inhibited Gram- positive bacteria with MIC values of 4.8 μM for S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]. |
Cell Viability Assay[1]
| Cell Line | RAW 264.7 macrophages |
|---|---|
| Concentration | 5 and 20 μg/mL |
| Incubation Time | 18 hours |
| Result | Observed LPS-stimulated production of NO with an inhibitory rate of 68.09% at 5 μg/mL. Exhibited inhibitory effects on the LPS-stimulated production of TNF-α with an inhibitory rate of 99.83% at 20 μg/mL. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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