| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H13N5O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antiproliferative agent-42 is a dihydrodipyrrolo compound that showed antiproliferative activity against the Panc-1 cell line, with an IC50 of 12.54 μM[1]. It has a molecular formula of C18H13N5O4 and a molecular weight of 363.33 g/mol.
Physical & Chemical Properties
| CAS Number | 3002404-74-9 |
|---|---|
| Molecular Formula | C18H13N5O4 |
| Molecular Weight | 363.33 g/mol |
| SMILES | O=C1NNC(C2=C1C(C3=CC([N+]([O-])=O)=CC=C3)=C4N2CCN5C4=CC=C5)=O |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Lish A B,et al. Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3‑d]pyridazine-8(9H)‑one Derivatives as Potential Cytotoxic Agents [J].[2023-11-08].
[2]. Barghi Lish, Azam, et al. "Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5, 6-dihydropyrrolo [2 ″, 1 ″: 3′, 4′] pyrazino [1′, 2′: 1, 5] pyrrolo [2, 3-d] pyridazine-8 (9 H)-one Derivatives as Potential Cytotoxic Agents." ACS Omega (2023).
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Panc-1 and PC3 as well as MDA-MB-231 cell lines can be inhibited by Antiproliferative agent-42 (0-100 μM, 48 h), with IC50 values of 12.5 μM, 17.7 μM, and 13.1 μM, respectively[1]. Sub-G1 phase arrest can be induced in Panc-1 cancer cells by Antiproliferative agent-42 (12.54 μM, 48 h)[1]. In Panc-1 cancer cells, the protein level of cleaved-caspase-3 and caspase-3 is turned down by Antiproliferative agent-42 (12.54 μM), while pro-caspase-3 protein level stays unchanged in Panc-1 cancer cells [1].
Apoptosis Analysis[1]
| Cell Line | Panc-1 |
|---|---|
| Concentration | 12.54 μM |
| Incubation Time | 48 h |
| Result | Induced apoptosis at 15.54 μM concentration (11.1%). |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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