| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C50H82BrO4P |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
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Compound Overview
Antitumor agent-73 is a diosgenin derivative that inhibits STAT3 signaling and exogenously activates Pdia3/ERp57. It shows potent anti-tumor activity against various cancer cell lines, 7.9- to 341.7-fold stronger than diosgenin itself[1]. Its molecular formula is C50H82BrO4P, with a molecular weight of 858.06 g/mol.
Physical & Chemical Properties
| CAS Number | 2812356-72-0 |
|---|---|
| Molecular Formula | C50H82BrO4P |
| Molecular Weight | 858.06 g/mol |
| SMILES | C[C@]1(CC2)C(C[C@H]2OC(CCCC[P+](C3CCCCC3)(C4CCCCC4)C5CCCCC5)=O)=CC[C@]6([H])[C@]1([H])CC[C@@]7(C)[C@@]6([H])C[C@@]8([H])[C@]7([H])[C@H](C)[C@@]9(CC[C@H](CO9)C)O8.[Br-] |
| Target | STAT3 |
| Signaling Pathway | JAK/STAT Signaling; Stem Cell/Wnt |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antitumor agent-73 is antiproliferative against cancer cells, with IC50s of 0.1847 μM for Aspc-1, 4.038 μM for H358, 4.001 μM for HCT116, and 0.4483 μM for SW620[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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