| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C29H31N5O2S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antitumor agent-86 inhibits MCF-7 breast cancer cells with an IC50 of 2.62 μM. It induces apoptosis and cell cycle arrest in these cells and displays antineoplastic activity through effects on the RAS/PI3K/Akt/JNK signaling cascades[1]. It has a molecular formula of C29H31N5O2S and a molecular weight of 513.65 g/mol.
Physical & Chemical Properties
| CAS Number | 2907704-65-6 |
|---|---|
| Molecular Formula | C29H31N5O2S |
| Molecular Weight | 513.65 g/mol |
| SMILES | COC1=CC(C2CC(C3=C(NC(NC3C4=CC=C(C=C4)N(C)C)=S)C)=NN2C5=CC=CC=C5)=CC=C1O |
| Signaling Pathway | PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antitumor agent-86 (0-200 μM; 48 h) dose-dependently suppresses proliferation of MCF-7, MDA-MB-231, Caco-2, and PANC-1 cancer cells, with IC50 values of 2.617, 6.778, 14.8 and 23.58 μM, respectively[1]. In MCF-7 cells, Antitumor agent-86 (2.62 μM; 48 h) induces apoptosis and cell cycle arrest and decreases p-RAS protein levels, PI3K and Akt mRNA transcript levels, and p-JNK protein expression[1]. Antitumor agent-86 (2.62 μM; 48 h) up-regulates p21 gene expression[1].
Cell Proliferation Assay[1]
| Cell Line | MCF-7, MDA-MB-231, Caco-2 and PANC-1 cell lines |
|---|---|
| Concentration | 0-200 μM |
| Incubation Time | 48 hours |
| Result | Dose-dependently suppressed cell proliferation of human cancer cell lines. |
Western Blot Analysis[1]
| Cell Line | MCF-7 cell line |
|---|---|
| Concentration | 2.62 μM |
| Incubation Time | 48 hours |
| Result | Decreased levels of p-JNK and p-RAS in MCF-7 cells. |
Apoptosis Analysis[1]
| Cell Line | MCF-7 cell line |
|---|---|
| Concentration | 2.62 μM |
| Incubation Time | 48 hours |
| Result | Induced cell apoptosis with morphological changess such as cell rounding and shrinkage with decreased cell number detachment and cytoplasmic condensation. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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