| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C27H24FN5O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Antiviral agent 15 is a Clofazimine derivative that exhibits antiviral effects. It inhibits both rabies virus and pseudo-typed SARS-CoV-2, with EC50 values of 1.45 μM and 14.6 μM, respectively[1]. It has a molecular formula of C27H24FN5O and a molecular weight of 453.51 g/mol.
Physical & Chemical Properties
| Molecular Formula | C27H24FN5O |
|---|---|
| Molecular Weight | 453.51 g/mol |
| SMILES | COC1=CC=C(N=C1)N2C3=CC=CC=C3N=C4C=C(/C(C=C42)=N/C(C)C)NC5=CC(F)=CC=C5 |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Antiviral agent 15 acts against rabies virus and SARS-CoV-2 proliferation: it targets the G or S protein to block viral membrane fusion, and binds the L protein or nsp13 to inhibit viral biosynthesis, respectively, which together produce a synergistic antiviral effect[1].
In Vivo
Kunming mice receive a single oral dose of Antiviral agent 15 at 0, 200, 400, 600, or 800 mg/kg, respectively. Over 7 days of close monitoring, all surviving mice had glossy hair, fleshy bodies, and good appetite[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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