| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (2E,3E)-4-(4-Chlorophenyl)-N-hydroxy-3-methyl-3-buten-2-imine |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Source | Synthetic |
| Storage |
AP-18 is a reversible antagonist of the TRPA1 ion channel, which is involved in sensing noxious stimuli and mediating pain and inflammation. In neuroscience, AP-18 is used to study TRPA1’s role in neurogenic inflammation, neuropathic pain, and sensory neuron excitability. By blocking TRPA1, AP-18 helps delineate the molecular mechanisms underlying pain perception and may contribute to the development of novel analgesics targeting TRP channels.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
AP-18 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-310)
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