| Field | Specification |
|---|---|
| Alternative names | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C15H10O5 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble to 50 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | White Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Apigenin is a naturally occurring flavonoid with neuroprotective and anti-inflammatory properties. It induces autophagy, a cellular degradation pathway essential for clearing damaged proteins and organelles, which is particularly relevant in neurodegenerative diseases. Apigenin also modulates cytochrome P450 enzymes, notably inhibiting CYP2C9, and has been shown to counteract the neurotoxic effects of immunosuppressants like cyclosporine. Its antioxidant activity and ability to cross the blood-brain barrier make it a promising candidate for therapeutic development in conditions such as Alzheimer's disease and Parkinson's disease.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R68 - Possible risk of irreversible effects
Apigenin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-249)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634.
3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.
