| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea |
| Cas No. | |
| Form | White to off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO, methanol, 100% ethanol or ethyl acetate |
| Source | Synthetic |
| Storage |
AR A014418 is a highly selective inhibitor of glycogen synthase kinase 3 (GSK-3), a serine/threonine kinase implicated in numerous neurodegenerative diseases. In neuroscience, AR A014418 is widely used to study tau phosphorylation, synaptic plasticity, and neuroinflammation. Its cell-permeable nature and specificity for GSK-3 make it a powerful tool for investigating therapeutic strategies in Alzheimer’s disease, bipolar disorder, and other CNS disorders.
Classification: Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Serious eye damage (Category 1), H318
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302 Harmful if swallowed.
- H315 Causes skin irritation.
- H318 Causes serious eye damage.
- H335 May cause respiratory irritation.
Precautionary statements:
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P271 Use only outdoors or in a well-ventilated area.
- P280 Wear protective gloves/ eye protection/ face protection.
- P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310 Immediately call a POISON CENTER or doctor/ physician.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P330 Rinse mouth.
- P332 + P313 If skin irritation occurs: Get medical advice/ attention.
- P362 Take off contaminated clothing and wash before reuse.
- P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.
AR A014418 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-492)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Gould T.D., Einat H., Bhat R., & Manji H.K. (2004) Int. J. Neuropsychopharmacology (CINP). 7(4): 387–390.
