| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H29ClN4O4S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AR-C141990 hydrochloride is a potent inhibitor of lactate transporters (monocarboxylate transporters; MCTs) with pKi values of 7.6 for MCT-1 and 6.6 for MCT-2[1]. It also has immunosuppressive properties and inhibits the graft-versus-host response[2]. It is supplied as a white to off-white solid (C26H29ClN4O4S, MW 529.05) at 98.2% purity.
Physical & Chemical Properties
| CAS Number | 2250019-94-2 |
|---|---|
| Molecular Formula | C26H29ClN4O4S |
| Molecular Weight | 529.05 g/mol |
| Purity | 98.2% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C1N(CC(C)C)C2=C(C(C(N3C[C@H](O)CC3)=O)=C(CC4=CC=NC5=CC=CC=C45)S2)C(N1C)=O.[H]Cl |
| Signaling Pathway | Membrane Transporter/Ion Channel |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
pKi: 7.6 (MCT-1) and 6.6 (MCT-2)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
MCT-3 (pIC50<5) and MCT-4 (pIC50<5) are not significantly affected by AR-C141990 hydrochloride[1]. In oocytes expressing MCT1 or 2, AR-C141990 hydrochloride inhibits the uptake of [3H]HOCPCA in a concentration-dependent manner, with IC50s of 0.21 μM and 2.32 μM, respectively[2].
In Vivo
In male NMRI mice (18-22 g), AR-C141990 hydrochloride (10 mg/kg; SC) shows a parallel decline in plasma concentrations and a half-life of around 20 minutes [2]. Corresponding plasma concentrations of AR-C141990 hydrochloride (0.3-90 mg/kg), when applied, cause the B/P of HOCPCA to decrease in a concentration-dependent way, with an EC50 of 860 ng/ml[2]. In PVG rats that received DA cardiac transplants, AR-C141990 (100 mg/kg; s.c.) moderately prolongs graft survival, for 40 days[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
Transcription factor Zhx2 is a checkpoint that programs macrophage polarization and antitumor response. Cell Death Differ 2023 Sep;30(9):2104-2119. PMID: 37582865
