| Field | Specification |
|---|---|
| Alternative names | BAX499 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ARC19499, also known as BAX499, is an aptamer that inhibits tissue factor pathway inhibitor (TFPI), thereby supporting clot initiation and propagation through the extrinsic pathway. The aptamer core binds tightly and specifically to TFPI, and it blocks TFPI-mediated inhibition of both factor Xa and the TF/factor VIIa complex. It corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood. It is supplied as a white to off-white solid with a molecular weight of 11078.95 g/mol.
Physical & Chemical Properties
| CAS Number | 1350667-54-7 |
|---|---|
| Molecular Weight | 11078.95 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | [ARC19499] |
| Signaling Pathway | Metabolic Enzyme/Protease; Cytoskeleton |
| Solubility | In Vitro: H2O: ≥ 100 mg/mL (9.03 mM) * "≥" means soluble, but saturation unknown. |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | ≥ 100 mg/mL (9.03 mM) | — |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
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Lipoprotein(a) prolongs ex vivo plasma clot lysis times through effects on clot formation rate and fibrin structure. J Thromb Haemost 2025 Oct 31:S1538-7836(25)00674-9. PMID: 41177455
