| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-[4-(diaminomethylideneamino)butyl]guanidine;sulfuric acid.
- CAS number: 14923-17-2
- Molecular formula: C6H18N6O4S.
- Purity: >95%
- Concentration: 50-500 µM.
- Form: Lyophilized powder.
- Solubility: 20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).
- Reconstitution: 20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NMDA receptors
- Source: Synthetic
- Activity: Arcane is an NMDA receptor antagonist with KD of 61 µM at -60 mV1.
Scientific background
Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to the ionotropic NMDA receptor to relay its excitatory signal.Arcaine sulfate is a competitive inhibitor of the NMDA receptor and also an inhibitor of the enzyme NO synthase. It has an effective concentration of 50-500 µM and an IC50 of 61 μM at -60 mV. Arcaine binds to the polyamine recognition site of the NMDA receptor complex and blocks the receptor in a concentration- and voltage-dependent manner. At positive membrane potentials Arcaine does not produce a blocking effect. In the presence of 100 μM Arcaine (at -60 mV), NMDA amplitude whole cell currents are reduced by 67% and by 69% in single channel recordings. The inhibitory effect of Arcaine is rapid in onset and recovery (
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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