| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Compositae Artemisia kotuchovii Kupr.; Plant — Umbelliferae |
| Molecular weight | |
| Molecular formula | C24H26O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Archangelicin inhibits cAMP-phosphodiesterase (cAMP-PDE) with an IC50 greater than 400 μM and inhibits nuclear factor of activated T cells (NFAT) with an IC50 of 9 μM. It exhibits antitumor and anti-inflammatory activity[1][2][3]. It has the molecular formula C24H26O7 (MW 426.46).
Physical & Chemical Properties
| CAS Number | 2607-56-9 |
|---|---|
| Molecular Formula | C24H26O7 |
| Molecular Weight | 426.46 g/mol |
| Structure Classification | Phenylpropanoids Coumarins |
| SMILES | C/C=C(C)\C(O[C@H]1[C@@H](C(OC(/C(C)=C\C)=O)(C)C)OC(C=C2)=C1C(O3)=C2C=CC3=O)=O |
| Signaling Pathway | Immunology/Inflammation; Metabolic Enzyme/Protease |
| Initial Source | Plant — Compositae Artemisia kotuchovii Kupr.; Plant — Umbelliferae |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: >400 μM (cAMP-PDE), 9 μM (NFAT)
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[3]. Nagasawa A, et al. Angular-type Furocoumarins from the Roots of Angelica atropurpurea and their Inhibitory Activity on the NFAT Signal Transduction Pathway[J]. Natural Product Communications, 2014, 9(12): 1934578X1400901218.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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