| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Liquid |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: (5Z,8Z,11Z,14Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]icosa-5,8,11,14-tetraenamide.
- Also known as: N-Vanillylarachidonamide
- CAS number: 128007-31-8
- Molecular formula: C28H41NO3.
- Purity: >96% (HPLC)
- Concentration: 1 nM - 1 µM.
- Form: Liquid
- Solubility: Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPV1 channels, CB1 receptors
- Source: Synthetic
- Activity: Arvanil is an agonist of TRPV1 channels (EC50 = 0.5 nM), a ligand of CB1 receptors (Ki = 0.25-0.5 μM), and an inhibitor of anandamide accumulation (IC50 = 3.6 µM). In vivo it demonstrates vasodilator, analgesic, and anti-inflammatory properties. Arvanil inhibits human breast cancer cell proliferation and the growth of astrocytoma xenograft tumors in mice1-3.
- Alternative names: N-Vanillylarachidonamide
Scientific background
Arvanil (N-Vanillylarachidonamide) is an agonist of TRPV1 channels and a ligand of CB1 cannabinoid receptors. Arvanil is a structural hybridization between the arachidonoyl group of anandamide (CB1 receptor ligand) and the vanillyl moiety of capsaicin1,2. Arvanil shows an EC50 value of 0.5 nM for TRPV1 receptors, and an IC50 value of 3.6 µM as an inhibitor of anandamide accumulation1.Studies have found that arvanil has the ability to induce dose-dependent apoptosis in the lymphoid Jurkat T-cell line2.CB1 receptors are important regulators of excitatory and inhibitory synaptic transmission in different areas in the brain. The receptor plays a crucial role in multiple sclerosis disease course and in mood control3.TRPV1 receptors are highly expressed in primary nociceptors. These channels can be activated by several stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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