| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H19BrF2N2O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
(aS)-PH-797804 is a selective p38 MAPK inhibitor, with IC50 values of 26 nM for p38α and 102 nM for p38β. It has anti-inflammatory activity[1][2]. It has the molecular formula C22H19BrF2N2O3 and a molecular weight of 477.30 g/mol.
Physical & Chemical Properties
| CAS Number | 1358027-80-1 |
|---|---|
| Molecular Formula | C22H19BrF2N2O3 |
| Molecular Weight | 477.30 g/mol |
| SMILES | O=C(NC)C1=CC(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C(C)C=C1.[(aS)-PH-797804] |
| Target | p38α, p38β |
| Signaling Pathway | MAPK/ERK Pathway |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
p38α 26 nM (IC50) |
p38β 102 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Sci Transl Med 2018 Jul 18;10(450):eaaq1093.
Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Cell Death Dis 2021 Oct 23;12(11):994. PMID: 34689152
Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis 2018 May 1;9(5):500.
Chondrocyte apoptosis in temporomandibular joint osteoarthritis promotes bone resorption by enhancing chemotaxis of osteoclast precursors. Osteoarthritis Cartilage 2022 Aug;30(8):1140-1153. PMID: 35513247
Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy. J Pharmacol Exp Ther 2019 Aug;370(2):219-230. PMID: 31189728
Disturbed Glycometabolism-Induced Chondrocyte Apoptosis Contributes to TMJOA. Oral Dis 2025 Oct 27. PMID: 41146398
bioRxiv. 2023 Feb 8.
