| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO, methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage |
Product details
- Chemical name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)- 17-ethyl-1,14-dihydroxy-12-[(1E)-1-[(1S,3S,4S)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0^{4,9}]octacos-18-ene- 2,3,10,16-tetrone.
- Also known as: Immunomycin, FK520
- CAS number: 11011-38-4
- Molecular formula: C43H69NO12.
- Purity: >99%
- Concentration: 10-100 nM.
- Form: Lyophilized Powder
- Solubility: DMSO, methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: DMSO, methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Source: Natural
- Activity: Ascomycin is an immunosuppressant antifungal antibiotic1,2. It also inhibits calcineurin (PP-2B) activity3.
- Alternative names: Immunomycin, FK520
Scientific background
Ascomycin (FK520) is a structurally complex macrolide with immunosuppressant activity. It is an ethyl analog of the known immune suppressant FK506 (Tacrolimus).1,2 Ascomycin acts by binding to a class of cytosolic proteins, the immunophilins, especially macrophilin-12 (FKBP-12). The immunophilin-FK520 complex inhibits calcineurin, a type 2B phosphatase (PP2B).3Ascomycin suppresses the production of Th1 and Th2 cytokines in T lymphocytes, and preferentially inhibits the activation of mast cells (principal cells of the allergic response).4 In human basophils, it potently inhibited anti-IgE-induced histamine and cytokine release, and reduced IgE-dependent p38 MAPK activation.5 It seems that Ascomycin inhibits basophil degranulation at the initial phase of allergic skin reactions.6,7 Ascomycin derivatives are currently developed for the clinical treatment of dermatological diseases.8,9
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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