| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C61H110N10O27 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ASGPR ligand-1 (Compound int-CC2) is a ligand for the asialoglycoprotein receptor (ASGPR) with a binding Kd value of 0.9 nM. It is applicable to research on lysosome degradation-related diseases[1]. It is supplied as a white to off-white solid (C61H110N10O27, MW 1415.58) at 95.87% purity.
Physical & Chemical Properties
| CAS Number | 1426160-58-8 |
|---|---|
| Molecular Formula | C61H110N10O27 |
| Molecular Weight | 1415.58 g/mol |
| Purity | 95.87% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(C)=O)=O)=O)(N)COCCC(NCCCNC(CCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(C)=O)=O)=O)=O)=O)=O |
| Signaling Pathway | Immunology/Inflammation |
| Solubility | In Vitro: DMSO: 10 mg/mL (7.06 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Martin Allan, et al. Targeted plasma protein degradation. Patent. WO2021156792
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 10 mg/mL (7.06 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
ASGPR ligand-1 shows a Kd of 0.9 nM for binding to ASGPR[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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