| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C33H40O7S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ASR-488 activates the mRNA-binding protein CPEB1, inducing apoptosis and inhibiting bladder cancer growth[1]. It is supplied as a white to off-white solid (C33H40O7S, MW 580.73) at 99.73% purity.
Physical & Chemical Properties
| CAS Number | 2690312-65-1 |
|---|---|
| Molecular Formula | C33H40O7S |
| Molecular Weight | 580.73 g/mol |
| Purity | 99.73% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | C[C@]([C@](CC[C@@]12C)([H])[C@@]([C@]1([H])CC[C@]2([H])[C@@H]([C@@](OC3=O)([H])CC(C)=C3CO)C)([H])C4)(C5=O)[C@@]6([C@H](C=C5)OC(C7=CC=CS7)=O)[C@]4([H])O6 |
| Signaling Pathway | Apoptosis |
| Solubility | In Vitro: DMSO: 100 mg/mL (172.20 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (172.20 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 2.5 mg/mL (4.30 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 2
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (4.30 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
At 0.2-12.5 μM (24-72 h), ASR-488 can potently induce apoptotic signaling and cause significant growth inhibition in TCCSUP and HT1376 cells[1].
Cell Proliferation Assay[1]
| Cell Line | BCa cell lines TCCSUP and HT1376 |
|---|---|
| Concentration | 0.2-12.5 μM |
| Incubation Time | 24, 48 and 72 h |
| Result | Showed that the IC 50 of TCCSUP was 800, 480 and 450 nM at different time periods of 24, 48 and 72 hours, and the IC 50 of HT1376 was 1.28 μM, 750 and 850 nM, respectively. Caused a downregulation of p65 and Bcl-2 expression and a marked increase in apoptosis in TCCSUP and HT1376 cells. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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